Investigation of in-vivo antigen-specific T cell responses. Autor: Univ. Prof. Dr. med. Dirk Busch. Introduction. The major focus of the Busch laboratory is. The inner layer antigen nanoparticles carried abundant antigens by self-cross-linking for persistent immune response, whereas the outer antigen. Donor antigen-specific immunomodulatory cells were generated ex vivo in the presence of anti-CD80/CD86 mAbs (2D/IT) or belatacept using. These results link responsiveness to a chronic viral antigen to in vivo proliferation of HIV-1–infected cells. Figure 2C shows clonal proviruses with defined. IL-2 Mutein Dosing and Antigen-Specific Immunotherapy. Minh N. Pham, Liliane Khoryati, Braxton L. Jamison, Erika Hayes, Jenna M. Circulating B cells must encounter cognate antigen to fulfill their unique function of producing high-affinity antibodies to combat infection. report that IFN-γ–primed human skin-derived mast cells can take up and process antigens and act as antigen-presenting cells (APCs) in vitro. We have devised a high-resolution flow cytometric strategy to quantify the emergence and maintenance of antigen-specific memory B cells directly ex vivo. Development of antigen-specific helper T cell responses in vivo: antigen-specific Th cell subsets. Academic Article. uri icon. Antigen-specific In Vitro Expansion of Functional Redirected NY-ESOspecific Human CD8+ T-Cells in a Cell-free System. GOPINADH JAKKA, PETRA C. SCHUBERTH.